The medicinal effects are either immunomodulatory or trophic or both. Moreover, transplanted MSCs promote functional recovery and myelin repair in different MS animal models. Abstract Adult mesenchymal stem cells (MSCs) have profound medicinal effects at body sites of tissue injury, disease, or inflammation as either endogenously or exogenously supplied. Importantly, MSCs induce oligodendrocyte fate decision and differentiation/maturation of adult neural progenitors, suggesting the existence of MSC-derived remyelination activity. MSCs display stromal features and exert bystander immunemodulatory and neuroprotective activities. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for MS. Therefore, novel MS therapies should consider not only immunemodulatory but also myelin repair activities. Despite the presence of endogenous oligodendroglial progenitors (OPCs) and of spontaneous remyelination, at least in early MS its levels and its qualities are apparently insufficient for a sustained endogenous functional repair. Current treatments reduce the relapse rate and the formation of inflammatory lesions in the CNS, but with only temporary and limited success. It is the most frequent neurological disease in young adults and affects over 2 million people worldwide. Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). The treatment protocol includes a two-day period of intravenous transplant of 300 million culturally expanded human umbilical cord tissue-derived adult mesenchymal stem cells (MSCs) and a variety of therapies designed to enhance stem cell activation and potency, such as physiotherapy, acupuncture, and lymphatic massage.
0 kommentar(er)
